Publications and Patents

Patents

US Patent Award 9,872,985. Glucose regulation via electrical stimulation of nerves innervating the liver. With Y. A. Patel. Awarded 2018 Jan 23.

US Patent Award 10,959,631. Neural interfacing device. With Y. A. Patel, J. D. Ross, S. Rajaraman, and I. Clements. Awarded 2021 Mar 30.

US Patent Award 10,981,007. System, methods, and devices for neuromodulation. With Y. A. Patel, T. Saxena, and R. V. Bellamkonda. Awarded 2021 Apr 20.

Books

R.J. Butera (EDITOR). Phase-Response Curves in Neuroscience: Theory, Experiment, and Applications. Co-editor with Astrid Prinz and Nathan Schultheiss (Emory University).  2013.  Springer Series in Computational Neuroscience.

Peer Review Journal Publications

Google Scholar Profile

ORCID profile

  1. R. J. Butera, J. W. Clark, D. A. Baxter, C. C. Canavier, and J. H. Byrne. “Analysis of the effects of modulatory agents on a modeled bursting neuron: dynamic interactions between voltage and calcium-dependent mechanisms.” Journal of Computational Neuroscience (1995) 2:19-44.
  2. R. J. Butera, J. W. Clark, and J. H. Byrne. “Dissection and reduction of a modeled bursting neuron.” Journal of Computational Neuroscience (1996) 3:199-223.
  3. S. S. Demir, R. J. Butera, A. A. DeFranceschi, J. W. Clark, and J. H. Byrne. “Phase-sensitivity and entrainment in a modeled bursting neuron.” Biophysical Journal (1997) 72:579-594.
  4. R. J. Butera, J. W. Clark, and J. H. Byrne. “Transient responses of a modeled bursting neuron: analysis with equilibrium and averaged nullclines.” Biological Cybernetics (1997) 77:307-322.
  5. C. C. Canavier, R. J. Butera, R. O. Dror, D. A. Baxter, J. W. Clark, and J. H. Byrne. “Phase response characteristics of model neurons determine whichpatterns are expressed in a ring circuit model of gait generation.” Biological Cybernetics (1997) 77:367-380.
  6. R. J. Butera. “Multirhythmic bursting.” Chaos (1998) 8:274-284.
  7. R. O. Dror, C. C. Canavier, R. J. Butera, J. W. Clark, and J. H. Byrne. “A mathematical criterion based on phase response curves for stability in a ring of coupled oscillators.” Biological Cybernetics (1999) 80:11-23.
  8. R. J. Butera, J. Rinzel, and J. C. Smith. “Models of respiratory rhythm generation in the pre-Botzinger complex: I. Bursting pacemaker neurons.” Journal of Neurophysiology (1999) 82:382-397.
  9. R. J. Butera, J. Rinzel, and J. C. Smith. “Models of respiratory rhythm generation in the pre-Botzinger complex: II. Populations of coupled pacemakers.” Journal of Neurophysiology (1999) 82:398-415.
  10. R. J. Butera, S. M. Johnson, C. A. DelNegro, J. Rinzel, and J. C. Smith.  “Dynamics of excitatory networks of bursting pacemaking neurons: Modeling and experimental studies of the respiratory central pattern generator.”  Neurocomputing (2000) 32:323-330.
  11. J. C. Smith, R. J. Butera, N. Koshiya, C. DelNegro, C. G. Wilson, and S. M. Johnson. “Respiratory rhythm generation in neonatal and adult mammals: The hybrid pacemaker-network model.” Respiratory Physiology & Neurobiology (2000) 122:131-147.
  12. C. A. DelNegro, S. M. Johnson, R. J. Butera, and J. C. Smith.  “Models of respiratory rhythm generation in the pre-Botzinger complex: III. Model predictions and experimental observations.”  Journal of Neurophysiology (2001) 86:59-74.
  13. R. J. Butera, C. G. Wilson, C. DelNegro, and J. C. Smith.  “A methodology for achieving high-speed rates of artificial conductance injection in electrically excitable biological cells.”  IEEE Transactions on Biomedical Engineering (2001) 48:1460-1470.
  14. C. G. Wilson, R. J. Butera, C. A. DelNegro, J. Rinzel, and J. C. Smith.  “Interfacing computer models with real neurons: respiratory ‘cyberneurons’ created with the dynamic clamp.”   Advances in Experimental Medicine and Biology (2001) 499:119-124.
  15. C. A. DelNegro, C. G. Wilson, R. J. Butera, and J. C. Smith.  “Unstable breathing rhythms and quasiperiodicity in the pre-Botzinger complex.” Advances in Experimental Medicine and Biology  (2001) 499:133-138.
  16. C. A. DelNegro, C. G. Wilson, R. J. Butera, H. Rigatto, and J. C. Smith.  “Periodicity, mixed-mode oscillations, and quasiperiodicity in a rhythm-generating neural network.”  Biophysical Journal  (2002) 82:206-214.
  17. C. A. DelNegro, N. Koshiya, R. J. Butera, and J. C. Smith.  “Persistent sodium current, membrane properties, and intrinsic bursting behavior of pre-Bötzinger Complex inspiratory neurons in vitro.”  Journal of Neurophysiology (2002) 88:2242-2250.
  18. B. Breen, W. C. Gerken, and R. J. Butera.  “Hybrid Integrate-and-Fire model of a bursting neuron.” Neural Computation (2003) 15:2843-2862.
  19. I. Raikov, A. J. Preyer and R. J. Butera. “MRCI: A flexible real-time dynamic clamp system for electrophysiology experiments.” Journal of Neuroscience Methods (2004) 132:109-123.
  20. M. Sekerli, C. A. Del Negro, R. H. Lee, and R. J. Butera.  “Estimating action potential thresholds from neuronal time-series: New metrics and evaluation of methodologies IEEE Transactions on Biomedical Engineering (2004) 51:1665-1672.
  21. R. J. Butera and M. L. McCarthy. “Analysis of real-time numerical integration methods applied to dynamic clamp experiments.” Journal of Neural Engineering (2004) 1:187-194.
  22. L. Purvis and R. J. Butera.  “An ionic current model of a hypoglossal motoneuron.”  Journal of Neurophysiology (2005) 93:723-733.
  23. M. Sekerli and R. J. Butera. “Oscillations in a simple neuromechanical system: Underlying mechanisms.” Journal of Computational Neuroscience (2005) 19:181-197.
  24. A. J. Preyer and R. J. Butera. “Neuronal oscillations in Aplysia californica that demonstrate weak coupling in vitro.” Physical Review Letters (2005) 95:138103 (5 pages).
  25. A. Sakurai, N. Dargouth, R. J. Butera, and P. S. Katz. “Serotonergic enhancement of a 4-AP-sensitive current mediates the synaptic depression phase of spike-timing dependent neuromodulation.” Journal of Neuroscience (2006) 26:2010-2021.
  26. J. Shao, T. Tsao, and R. J. Butera.  “Bursting Without Slow Kinetics:  A Role for a Small World?” Neural Computation (2006) 18:2029-2035.
  27. W. C. Gerken, L . K.Purvis, and R. J. Butera. “Genetic algorithm for optimization and specification of a neuron model.” Neurocomputing (2006) 69:1039-1042.
  28. M.S. Reid, E. A. Brown, R. J. Butera, and S. P. DeWeerth, “A Comparative Analysis of Multi-Conductance Neuronal Models in Silico.” Biological Cybernetics (2007) 96:181-194. (note: author ordership is incorrect as published; this represents the correct order).
  29. L. Purvis, J. C. Smith, H. Koizumi, and R. J. Butera. “Intrinsic Bursters Increase the Robustness of Rhythm Generation in an Excitatory Network.” Journal of Neurophysiology (2007) 97:1515-1526.
  30. T.-H. Tsao and R. J. Butera.  “Computational Model of TASK Channels and PKC-Pathway Dependent Serotonergic Modulatory Effects in Respiratory-Related Neurons.” Advances in Experimental Medicine and Biology  (2008) 605:382-385.
  31. J. Lewi, R. J. Butera, L. Paninski. “Sequential optimal design of neurophysiology experiments.” Neural Computation (2009) 21:619-687.
  32. A. J. Preyer and R. J. Butera. “Causes of Transient Instabilities in Dynamic Clamp Experiments.” IEEE Transactions on Neural Systems and Rehabilitation Engineering (2009) 17:190-198. PMC2748832.
  33. J. Cui, C. C. Canavier, and R. J. Butera. “Functional phase response curves: A method for assessing synchrony of adapting neurons.” Journal of Neurophysiology (2009) 102:387-398. PMC2712257.
  34. G. C. McConnell, R. J. Butera, and R. V. Bellamkonda.  “Bioimpedance modeling to monitor astrocytic response to chronically implanted electrodes.” Journal of Neural Engineering (2009) 6: 055005 (10 pages)
  35. L. Joseph and R. J. Butera. “Unmyelinated Aplysia nerves exhibit a non monotonic blocking response to high frequency stimulation.” IEEE Transactions on Neural Systems and Rehabilitation Engineering (2009) 17:537-544.
  36. J. Newman and R. J. Butera. “Mechanism, Dynamics, and Biological Existence of Multistability in a Large Class of Bursting Neurons.” Chaos  (2010) 20:023118 (8 pages) PMC2902537.
  37. S. Achuthan, R. J. Butera, and C. C. Canavier. “Synaptic and intrinsic determinants of the phase response curve for weak coupling.”  Journal of Computational Neuroscience (2011) 30:373-90. PMC3059351.
  38. P. Bradley, K. Wiesenfeld, and R. J. Butera. “Effects of heterogeneity in synaptic conductance between weakly coupled identical neurons.”  Journal of Computational Neuroscience (2011) 30:455-69.  PMC3059364.
  39. N. Toporikova and R. J. Butera. “Two modalities of bursting in inspiratory pacemakers: an integrative model.”  Journal of Computational Neuroscience (2011) 30:515-528. PMC3065506.
  40. N. Toporikova,  T.-H. Tsao, T. M. Wright, and R. J. Butera.  “Conflicting effects of excitatory synaptic and electric coupling on the dynamics of square-wave bursters.”  Journal of Computational Neuroscience (2011) 31:701-711.  PMC3190594.
  41. L. Joseph and R. J. Butera. “High frequency stimulation selectively blocks different types of fibers in frog sciatic nerve.” IEEE Transactions on Neural Systems and Rehabilitation Engineering (2011) 19:550-557. PMC3308706.
  42. R. M. Berry, J. Borenstein, and R. J. Butera. “Contentious Problems in Bioscience and Biotechnology: A Pilot Study of an Approach to Ethics Education.” Science and Engineering Ethics (2012). DOI: 10.1007/s11948-012-9359-6 (article is indexed by DOI)
  43. N. Toporikova and R. J. Butera.  “Dynamics of neuromodulatory feedback determines frequency modulation in a reduced respiratory network: A computational study.” Respiratory Physiology and Neurobiology (2013) 185:582-592. PMC3647346
  44. B. He, R. Baird, R. Butera, A. Datta, S. George, B. Hecht, A. Hero, G. Lazzi, R. C. Lee, J. Liang, M. Neuman, G. C. Y. Peng, E. J. Perreault, M. Ramasubramanian, M. D. Wang, J. D. Wikswo, G.-Z. Yang, Y.-T. Zhang. “Grand Challenges in Interfacing Engineering with Life Sciences and Medicine.” IEEE Transactions on Biomedical Engineering (2013) 60:589-598. PMID  23380847
  45. R. A. Gittens, R. Olivares-Navarrete, R. Rettew, R. J. Butera, F. M. Alamgir, B. D. Boyan, and Z. Schwartz. “Electrical polarization of titanium surfaces for the enhancement of osteoblast differentiation.” Bioelectromagnetics (2013) 38:599-612.  PMC4009505
  46. U. S. Thounaojam, J. Cui, S. E. Norman, R. J. Butera, and C. C. Canavier. “Slow noise in the period of a biological oscillator underlies gradual trends and abrupt transitions in phasic relationships in hybrid neural networks.” PLOS Computational Biology (2014) 10:e1003622.  PMC4022488
  47. F. A. Ortega, R. J. Butera, D. J. Christini, J. A. White, and A. D. Dorval. “Dynamic clamp in cardiac and neural systems using RTXI.” Methods in Molecular and Cell Biology (2014) 1183:326-354. PMID 25023319 (PMC in progress)
  48. Y.A. Patel and R. J. Butera. “Differential fiber-specific block of nerve conduction in mammalian peripheral nerves using kilohertz electrical stimulation.” Journal of Neurophysiology (2015).  113::3923-9.  PMID  25878155 (PMC4480619 accessible 2016-06-01)
  49. S. M. Norman, R. J. Butera, and C. C. Canavier. “Stochastic slowly adapting ionic currents may provide a decorrelation mechanism for neural oscillators by causing wander in the intrinsic period.” Journal of Neurophysiology (2016) 116:1189-98. PMC5018058
  50. Y.A. Patel, T. Saxena, R. V. Bellamkonda, and R. J. Butera. “Kilohertz frequency nerve block enhances anti-inflammatory effects of vagus nerve stimulation.” Scientific Reports (2017). 7: 39810. PMC5215548
  51. Y. A. Patel, A. George, A. Dorval, J. White, D. Christini, and R. J. Butera. “Hard real-time closed-loop electrophysiology with the Real-Time eXperiment Interface (RTXI).”  (2017) PLOS Computational Biology.  13(5):e1005430. PMC5469488
  52. Y. A. Patel, B. S. Kim, W. S. Rountree, and R. J. Butera. “Kilohertz electrical stimulation nerve conduction block: Effects of clectrode surface area.” (2017) IEEE Transactions on Neural Systems and Rehabilitation Engineering.  25(10):1906-1916. PMID 28328507
  53. Y. A. Patel, B. S. Kim, and R. J. Butera. “Kilohertz electrical stimulation nerve conduction block: Effects of electrode material.” (2018) IEEE Transactions on Neural Systems and Rehabilitation Engineering. 26(1):11-17. PMID 28809704
  54. Y. A. Patel and R. J. Butera. “Challenges associated with nerve conduction block using kilohertz electrical stimulation.” (2018) Journal of Neural Engineering. (2018) 15:031002 (10 pages). PMID 29415877
  55. J A. White, R. J. Butera, D. A. Gaver, et al. “Core Competencies for Undergraduates in Bioengineering and Biomedical Engineering: Findings, Consequences, and Recommendations” (2020) Annals of Biomedical Engineering 48(3):805-912. PMID 32026231
  56. N. J. Kirkpatrick, R. J. Butera, and Y-H Chang. “DeepLabCut increases markerless tracking efficiency in X-ray video analysis of rodent locomotion.” (2022) Journal of Experimental Biology. 225(16):jeb244540. PMID 35950365
  57. V. Tiruvadi, K. S. Choi, R. E. Gross, R. J. Butera, V. Jirsa, and H. Mayberg. “Dynamic oscillators evoked by Subcallosal Cingulate deep brain stimulation.” (2022) Frontiers in Neuroscience. 16:768355. PMID 35281513
  58. V. Tiruvadi, S. James, B. Howell, M. Obatusin, A. Crowell, P. Riva-Posse, R. E. Gross, C. C. McIntyre, H. S. Mayberg, and R. J. Butera. “Mitigating mismatch compression in differential local field potentials.” (2023) IEEE Transactions on Neural Systems and Rehabilitation Engineering. 31:68-77.  PMID 36288215
  59. S. Alagapan, K. S. Choi, S. Heisig, P. Riva-Posse, A. Crowell, V. Tiruvadi, M. Obatusin, A. Veerakumar, A. C. Waters, R. E. Gross, S. Quinn, L. Denison, M. O’Shaughnessey, M. Connor, G. Canal, J. Cha, R. Hershenberg, T. Nauvel, F. Isbaine, M. F. Afzal, M. Figgee, B. H. Kopell, R. Butera, H. S. Mayberg, C. J. Rozell. “Cingulate dynamics track depression recovery with deep brain stimulation.” (2023) Nature 622:130-138. PMID 37730990.